aminophylline infusion calculation

B Calculate the Infusion Rate of Aminophylline Solution 1mgml The usual dose range as stated in the BNFC1 and SORT2 guidelines. Dilute 500mg aminophylline in 500 mL sodium chloride 09 or glucose 5 to give a 1 mgml solution Administration.

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Usual range is 6001600 mgday PO in three to four divided doses.

. Per dose 5 mgkg to be followed by intravenous infusion. Aminophylline infusion rate mghour is multiplied by 24 to yield total daily dose of aminophylline. 1000 mL ----- mLhr 416 mlhr 42 mlhr for our pump rate 24 hours We need to give 3L of NS over 24 hours.

Severe acute asthma in patients not previously treated with theophyllinefor aminophylline. Low potassium level--leg cramps constipation irregular heartbeats fluttering in your chest numbness or tingling muscle weakness or limp feeling. Dose mghr x volume in syringe ml Amount in syringe mg Infusion rate.

Loading dose Desired concentration - measured concentration volume of distribution Mean volume of distribution. For example in non-smoking adults initiation of a constant intravenous theophylline infusion of 04 mgkghr 05 mgkghr as aminophylline at the completion of the loading dose on average will result in a steady-state concentration of. Use caution in younger children unable to complain of minor side effects.

High blood sugar--increased thirst increased urination dry mouth fruity breath odor. Aminophylline Injection BP may be given by slow intravenous injection or intravenous infusion in glucose injection or sodium chloride injection. Lets use the same examples.

1 mg aminophyllinekg ideal body weighthour as a constant infusion-Obtain a second serum theophylline concentration about one half-life after starting the infusion. Using the infusion strength you know that 1ml would administer 1mg of aminophylline so 225ml would administer 225mg. Of safety even if current dosage is tolerated.

Consider if overdose treatment required. I dont remember proper calculations we were taught in nursing school but it makes sense to me. 500microgramskghour 500micrograms x 70kg per hour 35000microgramshr 35mg per hour Add 500mg aminophylline to 500ml infusion fluid 1mgml concentration Set rate controlled infusion pump at 35ml per hour.

So 06x106ml Im pretty confident 6ml would be your answer. Therapeutic serum concentrations of theophylline are considered to range from 10 to 20 mcgml and. 20 to 249 Controlled No adverse reactions are present infusion rate by 25 20 to 249 Controlled Adverse reactions are present Stop infusion for 24 hours subsequent infusion rate at least 25 Adverse reactions symptoms Stop infusion for 24 hours.

Serious side effects may be more likely in older adults. Court Rules That States Medical Malpractice Act Can Apply to Nonpatients. 500mg per 10ml and want 300mg.

5mgkg 5mg x 70kg 350mg- add to 100ml of infusion fluid and administer over 20 minutes Maintenance Dose. Typically after steady-state is achieved with the intravenous aminophylline infusion the following procedure is used to calculate the oral theophylline dose. Rectal 500 mg q 68 hr by rectal suppository or retention enema.

Expressed as aminophylline Long-term therapy. The loading dose calculation must use the formula given below for patients who have taken aminophylline in the last 24 hours. The conventional aminophylline protocol used for group 1 patients consisted of a loading dose of 5 mgkg of body weight administered over 20 minutes followed by an infusion of 04 to 08 mgkgh.

This formula allows us to calculate this. This dose mgday is then multiplied by 08adjustment for the ethylenediamine. In this case 500ml500mg 1mlmg.

The manufacturer product information should be consulted. I always clarify every dose calculation with. Calculate initial dosage using the following equation.

A calculator used to determine the appropriate dosage of Theophylline. Under 12 Years 1 milligramkghour 12-17 years 05 to 07 milligramkghour Therefore the maintenance infusion rate range in ml per hour can be calculated as follows Required Dose Weight kg Infusion Rate. For example in non-smoking adults initiation of a constant intravenous theophylline infusion of 04 mgkghr 05 mgkghr as aminophylline at the completion of the loading dose on average will result in a steady-state concentration of.

Reduced doses may be needed in patients with risk factors for reduced theophylline clearance eg cardiac or liver dysfunction renal. Comments-Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required. Intravenous aminophylline therapy was initiated by the ED house staff one to four years postgraduate.

3000 ml ----- 125 mLhr 24 hours Complex Calculations. The equation for infusion rate calculation is dose stated in prescription milligrams per hour times volume in syringe in millilitres divided by the amount in the syringe in milligrams equals the infusion rate millilitres per hour or. Aminophylline infusion Find mghr DO mlhr SH gmml Dosage Calculation common icu drips icu iv drips icu drips management.

Per dose 500 mg to be followed by intravenous infusion. Rate 05 mgkghour rate is half patients weight see table below Dose and rate of aminophylline 1 mgml infusion Patient weight - kg use IBW if patient obese Dose mghr Infusion rate mlhr 40 20 20. Therefore 1ml of this infusion solution contains 1mg of aminophylline.

Aminophylline has a narrow therapeutic index therefore cautious dosage determination is essential. Here we need to change to mL 3000. PEDIATRIC PATIENTS Children are very sensitive to CNS stimulant action of theophylline.

We need to give 1000 mL of D5W over 24 hours. 0008 x age in weeks 021 theophylline dosage in mgkghour IV. We would therefore set the infusion rate as 225mlhour 225mg1 where 1 is the strength of the dosage in mlmg.

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